The 3 Bios
BioEngineering of BioInspired BioPolymers
Nano3Bio combines and integrates biotechnological production and nanotechnological formulation of innovative, bio-active, bio-mimetic, bio-inspired, and bio-engineered chitosans as high added value commodities for a range of applications within life sciences.
Bio-engineering is the application of biological concepts and methods to create solutions related to real-life requirements. It primarily uses the knowledge from molecular biology to advance applications of living organisms.
Bio-inspired materials and processes can be high added value commodities for a range of applications. Polysaccharides are the most versatile and most promising bio-materials.
Biopolymers are polymers produced by living organisms. They contain monomeric units that are covalently bonded to form larger structures. Their main classes are: polynucleotides (RNA, DNA), polypeptides and polysaccharides.
And what is the Nano about?
Nano3Bio includes different approaches to exploit current progress in nanobiotechnology under the same umbrella, i.e. biologically produced bio-inspired and nanostructured polymers with novel and improved bio-functionalities, biomineralization of physical chitosan hydrogels for bone repair, and the development of chitosan-based nanostructured materials, namely, nanoparticles, nanocapsules, and nanofibres to overcome solubility limitations of hitherto existing chitosans and to improve their bio-accessibility and bio-compatibility.
From first to third generation chitosans
A family of biomolecules with remarkable properties and functionalities.
First generation chitosans were rather poorly defined mixtures of polymers of varying purity and varying composition - mostly unfit for the development of successfully marketable products. These chitosans were dominating the market for decades and are still widespread today.
Second generation chitosans are well defined in terms of their degrees of polymerization and acetylation - more suitable for the development of reliable products due to known molecular structure-function relationships; these chitosans are now increasingly appearing on the market.
Third generation chitosans will be even less polydisperse, or even monodisperse in the case of oligomers, with non-random patterns of acetylation, defined biological activities, and known cellular modes of action; these chitosans will create new market opportunities in future.